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Data/Estimates Table showing creatine myoglobin creatine-kinase micrograms per gram in human flesh and blood (table is below intro text)
 
My commentary re the production of this table (first version finished June 26 '09):
 
I felt I had to improve my understanding regarding, looking at substances the body uses to deal with exercise, specifically myoglobin (oxygen storage/transport protein), creatine (energy storage transport and release amino acid), and various types of creatine kinases (enzymes such as CK-BB, CK-MB, CK-MM, Mito-CK that operate on creatine).
 
I needed to improve my understanding regarding what proportion of the total of all of these, each substance composing the total represents.
 
A super snack that increases the amount of work the body can do befor becoming fatigued, would IMHO have positive cardiac health effects. I did not feel comfortable trying to cook up said miraculous super-snack for consuming prior to exercise, without getting such an understanding.
 
I felt afraid of over-emphasizing or under-emphasizing some part of the whole. I felt that it would be easy to over or under emphasize for example a type of creatine kinase, or creatine itself, or myoglobin.
 
The different types of creatine kinase are composed differently in terms of the representation of various amino acids. The amino acid representation in creatine kinase is completely different compared to the molecular structure of creatine.
 
I was shocked that I had to put together this table you can see on this page below this text, from a million different sources, making estimates for values in table cells based on data obtained for other table cells.
 
I expected that this kind of table and the info I've gathered into it would be easy to find and would already have been created.
 
I estimate that the world's incompetence in this matter of negligence re producing said table, has to do with the error of failing to appreciate getting a good solid grasp of the overall big picture before delving into details. Fact is when you meddle with details you can end up disturbing and changing the overall big picture itself.
 
Nutritionists seem to forget that people have a limited amount of space in their stomach and putting one thing in the stomach gets in the way of putting another thing in the stomach. Similarly software developers produce software as if the assumption was that, the software user has as much time and mental energy to put into the software as the developer has been putting into it.
 
It was repeatedly annoying to, in the process of doing the hard work of researching out the table you can see below, continually encounter on the internet these persons making reports, who used measurements such as blah per liter, when the only way in which the blah per liter figure can be related to figures in other reports and studies, is to know certain hidden facts regarding the density and mass of blah-- yet at the same time the authors of the report do nothing to tell you the info you need to know about blah or point you in a direction where you could find such info.
 
Said annoyancing writers kept using irritating mysterious measurements such as U/liter, moles, umole, gmole, IU, etc etc. For sure obfuscation and pedantic pretentiousness are alive and well out there in internet-land.
 
The table I finally put together has allowed me to estimate that looking at myoglobin and creatine and the creatine kinases in the body all put together as a whole: myoglobin is in terms of milligram weight 72% of the total whole; creatine-kinase-MM is 20% of the total whole; creatine is 7% of the total whole; and, creatine-kinase-MB is 1% of the total whole.
Data/Estimates Table showing creatine myoglobin creatine-kinase micrograms per gram in human flesh and blood
 

















Substance

Representation
in blood
 
range (where available),
mean/average
 
in percent,
weight of substance
as percent of weight
of blood
x 10,000
Represen-
tation
in
cardiac
muscle
 
range,
mean/average

in percent,
weight of substance
as percent of weight
of tissue substance
embedded in
x 10,000
Represen-
tation
in
striated
skeletal
muscle
 
range,
mean/average
 
in percent,
weight of substance
as percent of weight
of tissue substance
embedded in,
x 10,000
 
Overall
 body
 
in percent,
weight of substance
as percent of weight
of tissue substance
embedded in,
x 10,000;
 
Above figure as percent of total of above
figure for  all rows

recomm
ended
dosage

Notes








Myoglobin
human
19-92
56
human
4000
human
21,000
(error?)
 
human
2000-12000
7000
 
my estimate for humans
11,056
 
72%

4% of iron in
body is in
myoglobin









Creatine
my est for humans,
60

my est
human
500
my estimate
human
500
 
rat white muscle
5000
 
rat red muscle
4000
 
top food sources
Herring, 7000;
Pork 5066;
Salmon & Beef,
4405;
Tuna, 3965
cod, 3084;
my estimate, for human,
1060
 
07%
0.3 mg/
kg
body
weight
 
17.5 mg/
kg body wt
 
avg of
above
two:
 
8.9 mg/kg
body wt,
 
641 mg
for 72 kg
person
In body 60% is phospho
creatine; 40% is free
creatine;
 
muscle contains 90%
of body's creatine pool
 
In humans half the daily
creatine needs supplied
by biosynthesis of
arginine, glycine, and methionine
 
120-140 g creatine stored
in body, 98% in muscle
 
70% is phosphocreatine
30% is free
 
replaced at rate of 20mg/kg/day;
 
used by 100% of rugby and weightlifters








total
creatine
kinase
human
10-150
80
my estimate,
4-1877
507

 
my estimate,
human,
2701
 
my estimate for humans,
3288
 
21%
(total of rows below)

constitutes 15.0000%
of 'muscle cytoplasmic
protein' (error?)









Creatine-kinase
-muscle
CK-MM
human
5-70
38
70%
of human cardiac
muscle creatine
kinase
 
my estimate:
human,
3-1288
348
 
50% of rat
cardiac muscle
creatine
kinase
my estimate,
human,
2646
 
98%
of human
skeletal
muscle
creatine kinase
my estimate for humans,
3032
 
20%

creatine and creatine-
kinase both decline in rats
with cancer








Creatine-kinase
muscle/brain
CK-MB
human
1-7
4
28% of human
cardiac muscle
creatine-kinase
 
19% of rat
cardiac muscle
creatine-kinase

in normal human
heart:
1-515
139
human:
27
 
1% of human
skeletal
muscle
creatine kinase
my estimate for humans,
170
 
01%










Creatine-kinase
brain
CK-BB
human
1
4% of rat
cardiac muscle
creatine-
kinase
 
my est, humans
09
my estimate
for human,
01;

 
my estimate
for human,
11
 
0%


'expressed at low
 levels in all tissues little clinical significance'
 
mainly produced by brain & smooth muscle








Mitochondrial
creatine-kinase
Mito-CK
my est for humans,
01
28%
of rat cardiac
muscle creatine
kinase
 
my estimate,
human,
0-37
10
my estimate,
human,
27
my estimate
for human,
38
 
0%











Totals
 



15,367
 
100%





























































































































































































 
Data based on:
 
http://www.nursingcenter.com/prodev/ce_article.asp?tid=718679

-- http://books.google.com/books?id=OQHmtQcIJIAC&pg=PA102&lpg=PA102&dq=myoglobin+%22micrograms+per%22&source=bl&ots=NGZMwm0D45&sig=3VpmIv01hkE7qrGOdp2IRWfjTf0&hl=en&ei=blxFSo6YOMrJtgfWtayQCw&sa=X&oi=book_result&ct=result&resnum=1

http://www.wellsphere.com/strength-training-article/the-creatine-dosage-calculation/145499
 
http://yourtotalhealth.ivillage.com/enzyme-tests.html?pageNum=4

-- http://www.biomedexperts.com/Abstract.bme/1424434/Myocardial_creatine_kinase-MB_concentration_in_normal_and_explanted_human_hearts_and_released_from_hearts_of_patients_wi
books.google.com/books?isbn=0683302736...
 
http://hubpages.com/hub/Creatine_vs_Glutamine_-_Part_2_-_Sources

http://74.125.47.132/search?q=cache:YEYldAUmCnsJ:www.actabp.pl/pdf/4_2004/875.pdf+CREATINE+MG+G+%22WET+WEIGHT%22&cd=48&hl=en&ct=clnk&gl=us
http://resources.metapress.com/pdf-preview.axd?code=y5ht432vhh25l7w1&size=largest
strange statement that myoglobin is 2.1% of human skeletal muscle:
http://jeb.biologists.org/cgi/reprint/207/20/3441.pdf
 
more believable report re myoglobin representation
(http://www.jbc.org/cgi/reprint/273/36/23426.pdf)
 
http://en.wikipedia.org/wiki/Creatine_kinase
 
 http://ajpendo.physiology.org/cgi/content/full/284/2/E399/T2
 
 http://www.pharmj.com/editorial/19991204/articles/creatine.html
 
statement that creatine-kinase represents 15% of 'muscle cytoplasmic protein'
http://www.worthington-biochem.com/CRK/default.html
 
http://www3.interscience.wiley.com/journal/120090317/abstract?CRETRY=1&SRETRY=0
 
 
@2009 David Virgil Hobbs